www.813.net-新葡亰平台游戏网址

LATEST PUBLICATIONS

The ISME Journal: Multi-omics analysis of niche specificity provides new insights into ecological adaptation in bacteria

Date:2018-07-14

Multi-omics analysis of niche specificity provides new insights into ecological adaptation in bacteria

Bo Zhu, Muhammad Ibrahim, Zhouqi Cui, Guanlin Xie, Gulei Jin, Michael Kube, Bin Li & Xueping Zhou

Abstract

Different lifestyles, ranging from a saprophyte to a pathogen, have been reported in bacteria of one species. Here, we performed genome-wide survey of the ecological adaptation in four Burkholderia seminalis strains, distinguished by their origin as part of the saprophytic microbial community of soil or water but also including human and plant pathogens. The results indicated that each strain is separated from the others by increased fitness in medium simulating its original niche corresponding to the difference between strains in metabolic capacities. Furthermore, strain-specific metabolism and niche survival was generally linked with genomic variants and niche-dependent differential expression of the corresponding genes. In particular, the importance of iron, trehalose and D-arabitol utilization was highlighted by the involvement of DNA-methylation and horizontal gene transfer in niche-adapted regulation of the corresponding operons based on the integrated analysis of our multi-omics data. Overall, our results provided insights of niche-specific adaptation in bacteria.


CONTACT US

Copyright ?  Institute of Biotechnology , Zhejiang University    login 

Addr: Agro-Sciences Complex Building-C, 866Yuhangtang Rd, Hangzhou 310058, P.R. China   E-mail: fushuai@zju.edu.cn


版权所有:www.813.net

XML 地图 | Sitemap 地图